Stem cell image of the month: A good head start
This colorful series of mouse skulls reveals stem cells, labeled with the protein Gli1, in the sutures between the calvaria bones in the upper part of the cranium.
Keck School alumnus helps bring $1 million gift to Keck Medicine
By Amy E. Hamaker
The strength of a university can often be measured by the commitment of its alumni. Nowhere is that more apparent than at the Keck School of Medicine of USC, where alumnus Tony Alamo (’91), MD, recently helped bring a gift of $1 million to the school from a family friend.
At a lunch between Alamo, Keck School Dean Carmen A. Puliafito, MD, MBA, and Mike Ensign, retired chairman of the board of directors/CEO of Mandalay Resort Group, Alamo suggested a gift to benefit physicians, Keck Hospital of USC and Keck School students. … Read More »
Exploring the connection between Alzheimer’s disease and stroke
By Shelby Roberts
Alzheimer’s disease is the No. 6 cause of death in the United States, and stroke is the No. 4 cause.
Helena Chui, MD, chair, Department of Neurology, Raymond and Betty McCarron Chair in Neurology, and professor of neurology and gerontology at the Keck School of Medicine of USC, recently gave a presentation on Alzheimer’s disease and its relation to stroke on Nov. 6 as the sixth lecture in an ongoing Stroke Seminar Series at the Rio Hando Community Center in Downey, Calif. The event was hosted by the Roxanna Todd Hodges Stroke Foundation. … Read More »
Top Trojan scientists converge at Neuroscience 2013
By Robert Perkins
Several key faculty members from USC presented the latest pioneering research in neuroscience at the Society for Neuroscience’s annual meeting in San Diego in November.
More than 30,000 scientists and collaborators from 80 countries gathered for presentations by luminaries in the field, including USC’s Antonio Damasio, MD, PhD, Berislav Zlokovic, MD, PhD, and Dan Campbell, PhD. … Read More »
BEST OF THE WURST
Students, faculty and staff on the Health Sciences Campus were treated to German music and a feast of bratwurst, sauerkraut, German potato salad, beer and pretzels to celebrate the coming of October — and the USC Good Neighbors Campaign. … Read More »
OT symposium convenes scholars of sensory integration research
By Mike McNulty
National experts on the sensory issues tied to autism and other neurodevelopmental disorders exchanged their respective research at the 24th USC Occupational Science Symposium, which brought together dozens of leaders from across the country to assess the field and prioritize future research directions.
Hosted by the USC Division of Occupational Science and Occupational Therapy and its Sensory Integration, Engagement and Family Program, more than 350 researchers, clinicians and educators attended the Nov. 7 event, titled “Sensory Integration at the Crossroads: Diverse Perspectives in Occupational Therapy Research.” … Read More »
USC researchers apply brainpower to understanding neural stem cell differentiation
By Cristy Lytal
How do humans and other mammals get so brainy? USC researcher Wange Lu, PhD, and his colleagues shed new light on this question in a paper published in Cell Reports on Oct. 24.
The researchers donned their thinking caps to explain how neural stem and progenitor cells differentiate into neurons and related cells called glia. Neurons transmit information through electrical and chemical signals; glia surround, support and protect neurons in the brain and throughout the nervous system. Glia do everything from holding neurons in place to supplying them with nutrients and oxygen, to protecting them from pathogens.
By studying early mouse embryo neural stem cells in a petri dish, Lu and his colleagues discovered that a protein called SMEK1 promotes the differentiation of neural stem and progenitor cells. At the same time, SMEK1 keeps these cells in check by suppressing their uncontrolled proliferation. … Read More »
Keck School Faculty Council discusses admissions, GME, research funding
By Amy E. Hamaker
The Keck School of Medicine of USC Faculty Council met in a Town Hall meeting on Oct. 15 at the Edmondson Faculty Center on the Health Sciences Campus to discuss medical recruitment, trends and financing in graduate medical education, research trends at the Keck School and faculty recruitment. … Read More »
Ostrow study illustrates how growth factor defect causes tongue malformation
By Beth Newcomb
New findings about how cell signaling directs tongue development may have big clinical applications for healing tongue defects, according to an Ostrow School of Dentistry of USC study in the Journal of Biological Chemistry.
Yang Chai, DDS, PhD, principal investigator of “Non-canonical transforming growth factor beta (TGFb) signaling in cranial neural crest cells causes tongue muscle developmental defects” and director of the Center for Craniofacial Molecular Biology at the Ostrow School of Dentistry, said the tongue is a unique, highly mobile muscular organ that many view as a “fifth limb.” When the tongue develops improperly or is damaged by injury or disease, it cannot regenerate on its own.
“The current standard of care is to repair the tongue surgically using a skin flap, but it doesn’t have the muscle components to move the tongue and lacks the ability to taste food,” explained Chai. “We want to understand how the tongue is formed and how we can use that knowledge to regenerate the tongue.” … Read More »
BREAST CANCER SURVIVORS, DOCTORS RECOGNIZED
In recognition of Breast Cancer Awareness Month, six Keck Medicine of USC breast cancer health-care professionals and six breast cancer survivors made an on-field appearance during halftime at the Oct. 26 USC Trojan football game vs. Utah State. … Read More »
Six USC professors named fellows of AAAS
By Robert Perkins
Four scientists from the Keck School of Medicine of USC have been elected fellows of the American Association for the Advancement of Science (AAAS), selected for the honor by their academic peers.
AAAS, the world’s largest general scientific society and the publisher of the journal Science, began the tradition of selecting fellows in 1874. The nonprofit organization has been around since 1848. … Read More »
Call to Cure supports USC Norris through art auctions
Art is supporting science thanks to DreamWorks Animation. Once per month for the next year, DreamWorks artists are donating original works for auction on eBay in support of Call to Cure, an organization supporting colorectal cancer research at USC. … Read More »
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… USC researchers to grow organs to unlock cancer tumor development
By Leslie Ridgeway
Using three-dimensional organ creation, Keck Medicine of USC researchers aim to discover clues to metastatic cancer growth by developing a first-ever integrated bioengineered/computational model of metastatic colon cancer.
David B. Agus, MD, director of the USC Center for Applied Molecular Medicine and professor of medicine at the Keck School of Medicine of USC, is the principal investigator of a $2.3 million, four-year “Provocative Questions” grant awarded recently by the National Cancer Institute (NCI), a division of the National Institutes of Health (NIH). The project title is “An Integrative Computational and Bioengineered Tissue Model of Metastasis.” … Read More »
Keck School Cell & Neurobiology chair receives AAMC teaching award
By Sara Reeve
For Mikel Snow, PhD, it’s an honor just to be nominated. The chair of the Keck School of Medicine of USC’s Department of Cell & Neurobiology has received the 2013 Alpha Omega Alpha (AOA) Robert J. Glaser Distinguished Teacher Award from the Association of American Medical Colleges (AAMC).
“I feel incredibly honored, even humbled by the magnitude of this award,” said Snow. “To be honest, I was deeply touched by the gesture of last year’s USC AOA [chapter] students who told me they would be nominating me. I do not think of myself in terms of anyone special, but rather someone who was fortunate to stumble into a teaching career that I happened to enjoy very much.” … Read More »
Keck Medicine and Operation Walk offered free joint replacements
By Amy E. Hamaker
Patricia Domay is a busy woman. At 72 years old, she caters for commercial video shoots, work she’s done for nearly 30 years. She grows her own organic vegetables, bakes an amazing coffee cake and charms those around her with her sunny personality.
In fact, the only thing that slows her down is her hip: The cartilage in Domay’s left hip joint has been worn away completely for nearly eight months, and the pain has taken its toll “My work is really strenuous,” she said. “Events are 10- to 12-hour days, plus an additional two days of prep work — all on my feet. I’ve always been very athletic — I’ve raced motorcycles, competed in tournament racquetball and hiked. It’s all hard on your body, but you don’t think about it when you’re young.” … Read More »
Dean’s Distinguished Lecturer discusses overeating, appetite in American culture
By Amy E. Hamaker
Have you ever felt driven to eat something sweet, even when you didn’t want to? The reason for this drive may be the high levels of sugar, fat and salt in food, which produce a dopamine hit that alters brain chemistry, according to David Kessler, MD, professor of pediatrics and epidemiology and biostatistics at the University of California, San Francisco, School of Medicine.
Kessler’s comments came during his lecture on Nov. 12 as part of the Dean’s Distinguished Lecture Series, held in Mayer Auditorium. His focus was from his book, The End of Overeating: Taking Control of the Insatiable American Appetite. … Read More »
L.A. benefactor pledges $5M to Alzheimer’s research at USC
Zlokovic named holder of newly endowed chair; brings total Zilkha giving to $30M
By Alison Trinidad
Los Angeles residents Selim Zilkha and Mary Hayley are raising the stakes in the fight against Alzheimer’s disease, the only cause of death among the top 10 in the United States that cannot currently be prevented, cured or slowed.
Zilkha, a member of the Keck School of Medicine of USC Board of Overseers, has pledged a gift of $5 million to the school to fund a new endowed chair in Alzheimer’s disease research. This latest gift brings Zilkha’s total giving to neuroscience research at the Keck School to more than $30 million. … Read More »