Common genetic disease linked to father’s age

By Robert Perkins

Scientists at USC have unlocked the mystery of why new cases of the genetic disease Noonan Syndrome are so common: a mutation that causes the disease disproportionately increases a normal father’s production of sperm carrying the disease trait.

When this Noonan syndrome mutation arises in a normal sperm stem cell, it makes that cell more likely to reproduce itself than stem cells lacking the mutation. The father then is more likely to have an affected child because more mutant stem cells result in more mutant sperm. The longer the man waits to have children the greater the chance of having a child with Noonan syndrome. … Read More »

June 24th, 2013|Announcements|

New USC research points to prospective avenue of treatment for Alzheimer’s patients

By Sara Reeve

A USC team of scientists has published research that highlights a new potential therapeutic agent for patients with Alzheimer’s disease.

Researchers from the Zilkha Neurogenetic Institute at the Keck School of Medicine of USC have found that a mutant protein helps to bind amyloid beta peptide in the brain more efficiently than a wild type — or naturally occurring — version. Amyloid beta peptide (Aβ) is a primary component of amyloid plaques — deposits found in the brains of Alzheimer’s disease patients — and most researchers believe it plays a central role in the development of Alzheimer’s.  … Read More »

June 24th, 2013|Announcements|

Keck School of Medicine of USC launches NIH-funded study to improve treatment for pre-diabetes and early type 2 diabetes

The Keck School of Medicine is looking for volunteers to take part in a National Institutes of Health-funded clinical trial, the BetaFat Study, to improve and preserve the production of insulin in people with prediabetes or recently diagnosed type 2 diabetes. … Read More »

June 24th, 2013|Announcements|

CHLA earns back-to-back top five rankings in the U.S. News & World Report survey

By Lorenzo Benet

For the fifth year in a row, Children’s Hospital Los Angeles has been named to the elite Honor Roll of the nation’s “best” children’s hospitals in the U.S. News & World Report rankings released online June 11.

Staffed by faculty from the Keck School of Medicine of USC, the hospital is often referred to as USC’s third campus. It is one of only 10 children’s hospitals in the country and the only West Coast pediatric medical center to make the list. Children’s Hospital Los Angeles also secured a fifth place overall national ranking, repeating its placement from last year’s survey. … Read More »

June 24th, 2013|Announcements|

Keck School alumnus Mitchell Lew named USC trustee

By Annette Moore

Mitchell W. Lew Photo/Dietmar Quistdorf Mitchell W. Lew
Photo/Dietmar Quistdorf

Physician, health care entrepreneur and longtime USC volunteer Mitchell W. Lew has been elected to the USC Board of Trustees. Lew is CEO of Prospect Medical Systems, an independent physician association with a network of primary care physicians, specialists and affiliated hospitals throughout Los Angeles, Orange and Riverside counties.

In May 2012, Lew became the first Asian-American president of the USC Alumni Association Board of Governors. Previously, he served as president of the USC Asian Pacific Alumni Association (APAA) from 2009 to 2011. … Read More »

June 21st, 2013|Announcements|

Gift of $90,000 makes the little things possible

By Amy E. Hamaker

The little things are what the Office of Patient and Family Experience at the Keck Medical Center of USC is all about.

The Patient Experience team welcomes and visits every patient within 24 hours of admission. During these visits, the staff answers any questions the patients or family members may have, checks on issues like staff responsiveness and room cleanliness, and makes sure that patients and their families feel cared for at USC’s hospitals. These initial connections help foster communication and trust between patients, their families and their medical care teams. … Read More »

June 21st, 2013|Announcements|

Physician departures reflect well on Keck faculty strength

By Josh Grossberg

Showing that the reputation of the Keck School of Medicine of USC is well regarded in the national medical community, three top doctors in their fields have been recruited for prestigious chairmanships at other institutions.

On July 1, Anthony Senagore will be leaving his position as professor in the Keck School and chief of colorectal surgery at Keck Medical Center of USC to accept a tenured position as chair of Surgical Disciplines at Central Michigan University School of Medicine.

Rohit Varma left his position as associate professor of ophthalmology and has accepted the chair of the Department of Ophthalmology and Visual Sciences at the University of Illinois at Chicago.

And Eila Skinner has left her post as associate professor of clinical urology to become chair of the Department of Urology at the Stanford School of Medicine. … Read More »

June 21st, 2013|Announcements|

Students present research at annual MD/PhD symposium

By Sara Reeve

As Tom Buchanan, vice dean for research of the Keck School of Medicine of USC, welcomed the room full of MD/PhD candidates to the annual USC-Caltech MD/PhD symposium, he had a very simple message — doing good science will make you happy.

“To me, at its core, science is fun,” he stated. “There are incredibly complicated structures in the world out there, and as a scientist, you get to figure out how the world works. … And medicine at its core is a real opportunity to do good for society. With an MD/PhD, you can make a difference in the way medicine is practiced. You can have an impact on a very large number of people while doing science, and I can’t think of a better thing than that.” … Read More »

June 21st, 2013|Announcements|

Research points to prospective treatment for Alzheimer’s patients

By Sara Reeve

A USC team of scientists has published research that highlights a new potential therapeutic agent for patients with Alzheimer’s disease.

Researchers from the Zilkha Neurogenetic Institute at the Keck School of Medicine of USC have found that a mutant protein helps to bind amyloid beta peptide in the brain more efficiently than a wild type — or naturally occurring — version. Amyloid beta peptide (Aβ) is a primary component of amyloid plaques — deposits found in the brains of Alzheimer’s disease patients — and most researchers believe it plays a central role in the development of Alzheimer’s. … Read More »

June 21st, 2013|Announcements|

In Memoriam: Don Harper Mills, 85

Don Harper Mills, a longtime clinical professor of pathology and psychiatry at the Keck School of Medicine of USC, died May 21. He was 85.

Don Harper Mills Don Harper Mills

Mills, who taught at the Keck School and was a past president of Salerni Collegium, was also a practicing attorney. He served as medical director of the County of Los Angeles Medical Malpractice Program, devoted to claims management for the public hospitals and clinics in the county. … Read More »

June 21st, 2013|Announcements|

Research team awarded $11 million grant to fight stroke

By Josh Grossberg

USC researchers and their partners across Los Angeles County have been awarded an $11 million grant to fund research on community-based interventions to reduce the higher rates of stroke and death from stroke among economically disadvantaged Hispanics, African-Americans and Asian-Americans.

Amytis Towfighi Amytis Towfighi

The Los Angeles Stroke Prevention/Intervention Research Program in Health Disparities is a multi-partnered research center, funded by the National Institutes of Health. The center, led by Barbara Vickrey, professor of neurology at UCLA, will conduct two randomized, controlled community-based trials of stroke prevention interventions.

Amytis Towfighi, assistant professor of neurology at the Keck School of Medicine of USC and associate chief medical officer of Rancho Los Amigos National Rehabilitation Center, will co-lead the larger trial in the five-year study.

“The reason we’re targeting this population is because minorities are at high risk for stroke and are less likely to receive appropriate stroke preventive services than whites,” Towfighi said. “We plan to bridge this gap.” … Read More »

May 16th, 2013|Announcements|

New research elucidates a complex gene regulatory circuit

By Candace Pearson

Piece by missing piece, scientists at the Keck School of Medicine of USC are deciphering the powerful gene regulatory circuit that maintains and controls the potential of embryonic stem cells (ESCs) to form any type of cell in the body.

Recent findings by Andrew McMahon, director and Provost Professor, and Qilong Ying, associate professor of cell and neurobiology, at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, underscore the essential role of basic science in paving the way for future medical breakthroughs. … Read More »

May 16th, 2013|Announcements|

Director of global health sees cause for optimism on climate change

By Ina Fried

Images of shrinking glaciers and stranded polar bears give powerful evidence of the need for people to work together on the common problem of protecting the planet. Adding art and the voices of community leaders to the data scientists are compiling may help convince decision makers to take action to deal with climate change, said Jonathan Samet, director of the USC Institute for Global Health.

Samet spoke on challenges and opportunities in arts and health care and the need for stewardship of the planet at an Earth Day Forum on April 22 at Los Angeles City Hall. … Read More »

May 16th, 2013|Announcements|

CHLA names Levitt inaugural director of Developmental Neurogenetics

By Ellin Kavanagh

Pat Levitt, USC Provost Professor of Neuroscience, Pharmacy, Psychiatry, Pediatrics and Psychology, has been named inaugural director of the Developmental Neurogenetics Program of the newly created Institute for the Developing Mind within The Saban Research Institute of Children’s Hospital Los Angeles.

The Institute for the Developing Mind, envisioned to become an internationally recognized center for innovative research, diagnosis and treatment of neurodevelopmental and behavioral disorders, will provide comprehensive, interdisciplinary research and clinical services at CHLA and the Keck School of Medicine of USC. … Read More »

May 16th, 2013|Announcements|

Psychiatry resident wins two key awards

By Josh Grossberg

Beating out hundreds of entrants, a third-year psychiatry resident at the Keck School of Medicine of USC has recently been named the winner of two separate prestigious awards.

Sean Sassano-Higgins was one of only 13 people in the country chosen for a GAP Fellowship, awarded by the Group for the Advancement of Psychiatry. … Read More »

May 16th, 2013|Announcements|

Alligator stem cell study gives clues to tooth regeneration

By Alison Trinidad

Alligators may help scientists learn how to stimulate tooth regeneration in people, according to new research led by the Keck School of Medicine of USC.

For the first time, a global team of researchers led by USC pathology professor Cheng-Ming Chuong, has uncovered unique cellular and molecular mechanisms behind tooth renewal in American alligators. Their study, titled “Specialized stem cell niche enables repetitive renewal of alligator teeth,” appears in Proceedings of the National Academy of Sciences. … Read More »

May 16th, 2013|Announcements|

Cinical trial examines natural alternatives to estrogen

By Molly Rugg

Physicians and neuroscientists at USC are enrolling female volunteers into a National Institutes of Health-funded clinical trial studying the effects of soy supplements on menopause-related hot flashes and memory loss. Sponsored by the Keck School of Medicine of USC and USC School of Pharmacy, the clinical trial will examine how healthy peri- and post-menopausal women tolerate a nutritional supplement called phytoSERM.

PhytoSERMs are a food supplement that contain three different phytoestrogens: daidzen, genistein and equol. Phytoestrogens are naturally occurring compounds derived from plants and function like the primary female sex hormone—estrogen.

… Read More »

May 10th, 2013|Announcements|

Cutting-edge surgery

The USC Institute of Urology hosted “L.A. Live—International Robotic and Open Live Surgery Symposium,” which attracted more than more than 240 physicians to the Aresty Auditorium from May 1-2. A roster of 40 renowned international surgeons served as speakers and moderators for the event, which featured 10 live robot-assisted and open surgeries. The event was designed to help improve robotic skills for all levels of surgeons. … Read More »

May 10th, 2013|Announcements|

USC researchers reveal cellular process that thwarts viruses

By Robin Heffler

The human body has the ability to ward off viruses by activating a naturally occurring protein at the cellular level, setting off a chain reaction that disrupts the levels of cholesterol required in cell membranes to enable viruses to enter cells.

The findings, discovered by researchers in molecular microbiology and immunology at the Keck School of Medicine of USC, hold promise for the development of therapies to fight a variety of viral infections.

“Previous studies have shown that our bodies are already equipped to block viruses such as Ebola, influenza, West Nile and SARS,” said Jae U. Jung, principal investigator and distinguished professor and chair of the Molecular Microbiology and Immunology Department.

The study, “The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry,” was published in the journal Cell Host & Microbe on April 17. … Read More »

May 10th, 2013|Announcements|

Laboratory of Neuro Imaging Moves to USC

Arthur Toga Arthur Toga

By Suzanne Wu

USC is about to get even brainier. Already a leading center for research on the neurological basis of emotion, the university announced today a major cluster hire of an institute with 110 faculty, researchers and multidisciplinary staff in the field of brain mapping and neuroimaging—the critical work that allows us to actually see the physical structure and circuitry that generates our mind, behavior and consciousness.Headlining the move are Arthur W. Toga, professor of neurology and co-director of the Division of Brain Mapping in the Neuropsychiatric Institute at UCLA, and Paul Thompson, professor of neurology and psychiatry at UCLA. Toga is director of the Laboratory of Neuro Imaging (LONI), which will come to USC in the fall, bringing with it a full faculty contingent and international research collaborations.

“USC prides itself on recruiting transformative faculty who excel in their own fields of interest and whose affinity for collaboration helps erase the boundaries between disciplines,” said USC President C. L. Max Nikias. “This cluster hire will help us move one step closer to understanding the structure and function of the human brain. Professors Toga and Thompson—and their talented team—will enhance the quality of this research at USC and improve the lives of people around the world.”

… Read More »

May 10th, 2013|Announcements|