A research team from the Keck School of Medicine of USC and City of Hope has uncovered details about gliomas, including glioblastomas, that may ultimately inform personalized therapies.

The preclinical study, funded in part by the National Institutes of Health, used DNA and RNA sequencing, as well a cutting-edge method known as spatial transcriptomics, to analyze key genes in brain cancer tumors and their immediate surroundings, known as the tumor microenvironment.

The findings, published in Nature Communications, paint a detailed picture of how genetic changes within brain tumors fuel their growth and survival, setting the stage for future studies that delve deeper into the exact biological mechanisms at play. It also suggests how personalized medicine may be effective against gliomas, for example, by delivering several different treatments to target each subclone within a given tumor.

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