In a first for USC Stem Cell scientists, the Quadrato Lab has pioneered a novel human brain organoid model that generates all the major cell types of the cerebellum, a brain region predominantly made up of two cell types necessary for movement, cognition and emotion: granule cells and Purkinje neurons.

This marks the first time that scientists have succeeded in growing Purkinje cells that possess the molecular and electrophysiological features of functional neurons in an all-human system. Details of the achievement have been published in the Science Direct publication Cell Stem Cell.

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