USC President Carol L. Folt and Children’s Hospital Los Angeles President and Chief Executive Officer Paul S. Viviano announced on Monday a new, $40 million partnership in biomedical research and innovation initiatives to improve health care.

The gift marks the final distribution of an original donation made to USC in 1985 by the late inventor and entrepreneur Alfred E. Mann, whose total giving to the university reached $230 million over the course of 25 years.

The gift to CHLA will benefit the work of Keck School of Medicine of USC faculty, who lead the clinical care at the hospital. CHLA provides clinically superior, specialized and complex pediatric care, reaching 1 in 3 children annually in Los Angeles County alone.

“Today’s announcement is testament to the power of connection — between a visionary entrepreneur’s generosity and two recognized leaders in biomedical research and innovation,” Folt said.

In February, Folt celebrated the naming of the USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences with a $50 million endowment from the Alfred E. Mann Charities and Alfred E. Mann Foundation for Biomedical Engineering.

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