Colorectal cancer is the second leading cause of cancer-related mortality worldwide with a poor 5-year survival rate in patients with metastatic colorectal cancer. Patients with metastatic colorectal cancer treated with first-line standard-of-care chemotherapy have shown to have poor outcomes.

Now, results from a new study published in the Journal of Clinical Oncology reveal that a combination of Nivolumab plus low-dose ipilimumab, two immune therapeutic agents approved in refractory microsatellite high cancers, were used for the first time in newly diagnosed MSI H metastatic colorectal cancer and demonstrated robust and durable clinical benefit and was very well tolerated as a first-line treatment for metastatic colorectal cancer.

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