A globe-spanning research team has compiled the most comprehensive list of genetic variants associated with prostate cancer risk — 451 in all, including 187 newly discovered variants — through a whole-genome analysis that ranks as the largest and most diverse investigation into prostate cancer genetics yet.

The research, led by the Keck School of Medicine of USC’s center for genetic epidemiology and the USC Norris Comprehensive Cancer Center, with partnership from The Institute of Cancer Research, London, studied genomic information from close to 950,000 men with major increases in representation among men from racial and ethnic groups that have often been left out of such research.

As a result, prostate cancer risk prediction methods are about to become more effective — even distinguishing between the likelihood of aggressive and less-serious cases among men of African descent.

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