USC study sheds light on stem cell reprogramming

By Josh Grossberg

Researchers are learning how to turn regular cells into stem cells, a process called reprogramming. However, some of the mechanisms of the process remain unknown, such as why only a small proportion of the cells can be reprogrammed. Researchers have at least part of the answer: the structure of genes.

“Nobody knows anything about how the 3-D genome structure is reorganized during reprogramming,” said Wange Lu, associate professor at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC and the Department of Biochemistry and Molecular Biology at the Keck School of Medicine of USC. “But we found out that it is a very important process. If the structure is not established correctly, the cells may cause diseases when they are used later in clinical applications.”

Lu and his team have made a series of discoveries that shed light on the process. Their findings have been published in the July issue of Cell Stem Cell. Read More »

July 12th, 2013|Announcements|

New research elucidates a complex gene regulatory circuit

By Candace Pearson

Piece by missing piece, scientists at the Keck School of Medicine of USC are deciphering the powerful gene regulatory circuit that maintains and controls the potential of embryonic stem cells (ESCs) to form any type of cell in the body.

Recent findings by Andrew McMahon, director and Provost Professor, and Qilong Ying, associate professor of cell and neurobiology, at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, underscore the essential role of basic science in paving the way for future medical breakthroughs. Read More »

May 16th, 2013|Announcements|