By Alison Trinidad
Exposure to air pollution appears to increase the risk for autism spectrum disorder (ASD) among people who carry a genetic disposition for the disorder, according to newly published research led by scientists at the Keck School of Medicine of USC.
“Our research shows that children with both the risk genotype and exposure to high air pollutant levels were at increased risk of autism spectrum disorder compared to those without the risk genotype and lower air pollution exposure,” said the study’s first author, Heather E. Volk, PhD, MPH, assistant professor of research in preventive medicine and pediatrics at the Keck School and principal investigator at The Saban Research Institute of Children’s Hospital Los Angeles.
The study, “Autism spectrum disorder: Interaction of air pollution with the MET receptor tyrosine kinase gene,” appeared in the January 2014 issue of Epidemiology.
ASD is a lifelong neurodevelopmental disability characterized by problems with social interaction, communication and repetitive behaviors. The U.S. Centers for Disease Control and Prevention estimates that one in 88 children in the United States has an ASD.
ASD is highly heritable, suggesting that genetics are an important contributing factor, but many questions about its causes remain. There currently is no cure.
“Although gene-environment interactions are widely believed to contribute to autism risk, this is the first demonstration of a specific interaction between a well-established genetic risk factor and an environmental factor that independently contribute to autism risk,” said Daniel B. Campbell, PhD, assistant professor of psychiatry and the behavioral sciences at the Keck School and the study’s senior author. “The MET gene variant has been associated with autism in multiple studies, controls expression of MET protein in both the brain and the immune system, and predicts altered brain structure and function. It will be important to replicate this finding and to determine the mechanisms by which these genetic and environmental factors interact to increase the risk for autism.”
Independent studies by Volk and Campbell have previously reported associations between autism and air pollution exposure and between autism and a variant in the MET gene. The current study suggests that air pollution exposure and the genetic variant interact to augment the risk of ASD.
Campbell and Volk’s team studied 408 children between 2 and 5 years of age from the Childhood Autism Risks From Genetics and the Environment Study, a population-based, case-controlled study of preschool children from California. Of those, 252 met the criteria for ASD. Air pollution exposure was determined based on the past residences of the children and their mothers, local traffic-related sources, and regional air quality measures. MET genotype was determined through blood sampling.
Campbell and Volk continue their work in studying the interaction of air pollution exposure and the MET genotype in mothers during pregnancy. Their work was supported by grants from the National Institute of Environmental Health Sciences (grant numbers ES019002, ES013578, ES007048, ES11269, ES015359, ES016535, ES011627, EPA Star-R, 823392, 833292), the MIND Institute, and Autism Speaks.